Christopher M. Adams, MD, PhD
Dept. of Internal Medicine
Dept. of Molecular Physiology and Biophysics
Abboud Cardiovascular Research Center
FOE Diabetes Research Center
Pappajohn Biomedical Institute
Welcome to the Adams Lab
Our laboratory's research is focused on causes and treatment of skeletal muscle atrophy, a common and debilitating condition that diminishes the health and quality of life of many patients with diabetes. To better understand causes of muscle atrophy, we are investigating how conditions such as diabetes alter muscle gene expression, and how these changes in gene expression cause muscle atrophy. Because a pharmacologic therapy for muscle atrophy does not exist, we are using systems-based strategies to search for a therapy. Thus far, we have discovered several small molecules that inhibit muscle atrophy, including ursolic acid, a natural compound found in apple peels and other edible plant materials. At least some of these small molecules also reduce obesity and blood glucose. We are now pursuing these small molecules as potential therapeutic agents for patients with muscle atrophy, obesity and diabetes.
OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.
Pereira RO, Tadinada SM, Zasadny FM, Oliveira KJ, Pires KMP, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED.
EMBO J. 2017 Jul 14;36(14):2126-2145. doi: 10.15252/embj.201696179. Epub 2017 Jun 12.
Role of ATF4 in skeletal muscle atrophy.
Adams CM, Ebert SM, Dyle MC.
Curr Opin Clin Nutr Metab Care. 2017 May;20(3):164-168. doi: 10.1097/MCO.0000000000000362.
Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG.
J Biol Chem. 2017 Apr 21;292(16):6786-6798. doi: 10.1074/jbc.M116.768408. Epub 2017 Feb 27.
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells.
Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.
JCI Insight. 2016 Nov 3;1(18):e88646.
Amino Acid Sensing in Skeletal Muscle.
Moro T, Ebert SM, Adams CM, Rasmussen BB.
Trends Endocrinol Metab. 2016 Nov;27(11):796-806. doi: 10.1016/j.tem.2016.06.010. Epub 2016 Jul 19. Review.
Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence.
Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH.
Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E594-604. doi: 10.1152/ajpendo.00257.2016. Epub 2016 Jul 5. Review.
Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4.
Bullard SA, Seo S, Schilling B, Dyle MC, Dierdorff JM, Ebert SM, DeLau AD, Gibson BW, Adams CM.
J Biol Chem. 2016 Aug 19;291(34):17496-17509. doi: 10.1074/jbc.M116.740308. Epub 2016 Jun 29.